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May 6, 2026International Journal of Dermatology

Evidence of Increased 3‐Alpha‐Androstanediol Glucuronide in Female Pattern Alopecia: A Cross‐Sectional Observational Study Evaluating Ovarian, Adrenal, and Peripheral Androgens

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Authors

AKArunesh Padmini KathirveluKSKabir SardanaLSLokesh Kumar Sharma

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Overview

Cross-sectional study found higher 3-alpha-androstanediol glucuronide in FPHL patients, suggesting its role in antiandrogen therapy.

Key Points

  • To evaluate the role of androgens, particularly 3α-diol G, in the severity of female pattern hair loss.
  • Cross-sectional observational study in Indian women with confirmed FPHL and healthy controls.
  • Measured serum levels of androgens including 3α-diol G, total testosterone, SHBG, and others.
  • Assessed FPHL severity using Ludwig and Sinclair scales.
  • 3α-diol G levels were significantly higher in FPHL patients compared to controls (p < 0.001).
  • Positive correlation found between 3α-diol G levels and FPHL severity (Spearman's ρ = 0.37, p = 0.013).
  • High diagnostic accuracy for 3α-diol G with AUROC of 0.85, suggesting its potential as a biomarker for monitoring antiandrogen therapy.

Cite This Study

Kathirvelu et al. (2026) studied this question.

synapsesocial.com/papers/69fa8e8904f884e66b530ccchttps://doi.org/10.1111/ijd.70445
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