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May 6, 2026The Journal of Dermatology

Immunohistochemistry Revealed Distinct IL ‐36γ Localization Among Different Skin Diseases

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Authors

MKMegumi KishimotoMKMiho Kimura-SashikawaMKMayumi Komine

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Overview

Immunohistochemistry reveals IL-36γ localization differences among skin diseases, suggesting distinct inflammatory mechanisms.

Key Points

  • To investigate the localization of IL-36γ in various inflammatory skin diseases and its possible implications.
  • Used immunohistochemistry to assess IL-36γ localization in skin specimens from various patients.
  • Patients included those with psoriasis vulgaris, generalized pustular psoriasis, and other skin diseases.
  • Staining scores were determined based on intensity and distribution, with a focus on nuclear positivity.
  • IL-36γ was highly expressed in the upper epidermis of psoriasis vulgaris and generalized pustular psoriasis.
  • Nuclear positivity was 92% in psoriasis vulgaris and 100% in generalized pustular psoriasis, but absent in pyoderma gangrenosum.
  • The staining scores for psoriasis vulgaris were significantly higher compared to atopic dermatitis.

Cite This Study

Kishimoto et al. (2026) studied this question.

synapsesocial.com/papers/69fa8eac04f884e66b53106ahttps://doi.org/10.1111/1346-8138.70291
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