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May 6, 20260 citations

Rv3875 Drives TRIM21 Expression in Macrophages via Type I Interferon to Enhance Mtb Growth

Mycobacterium tuberculosis Rv3875 upregulates TRIM21 expression through the type I interferon/STAT1 pathway and promotes intracellular growth.

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Authors

RXRuiYao XuYHYuxing HuangGWGaoyan Wang

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Overview

Experiment unveils Rv3875 as a virulence factor enhancing TRIM21 in macrophages, suggesting pathways for tuberculosis treatment.

Key Points

  • To investigate the role of Rv3875 in upregulating TRIM21 and its effects on Mycobacterium tuberculosis intracellular growth.
  • Screening of Mtb secretory proteins to identify Rv3875 as a virulence factor
  • Analysis of TRIM21 expression in macrophages
  • Examination of the interferon signaling pathway
  • Assessment of ferritinophagy involved in bacterial survival
  • Rv3875 significantly upregulates TRIM21 expression in macrophages
  • TRIM21 induction facilitates NCOA4-dependent ferritinophagy
  • Type I interferon signaling pathway is activated, leading to increased IFN-β production
  • Identified Rv3875-TRIM21-NCOA4 axis as critical for Mtb pathogenicity

Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/69fa8eac04f884e66b531076https://doi.org/10.1016/j.micpath.2026.108528
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