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May 6, 2026BiomoleculesOpen Access

Deciphering Lipid Metabolic Landscape of Sorafenib-Treated Hepatocellular Carcinoma by Mass Spectrometry Imaging and Transcriptomics

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Authors

DLD C LiYTYuanyuan TuoLSLuheng Sai

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Overview

Mass spectrometry imaging reveals sorafenib alters lipid metabolism and immune environment in hepatocellular carcinoma.

Key Points

  • Investigate the impact of sorafenib on lipid metabolism and the immune microenvironment in hepatocellular carcinoma.
  • Used high-resolution mass spectrometry imaging to profile lipid changes in 3D HepG2 spheroids after sorafenib treatment.
  • Employed immunohistochemical and immunofluorescence techniques to evaluate immunological effects in an orthotopic mouse model.
  • Conducted transcriptomic analysis and Q-PCR for gene expression profiling.
  • Performed molecular docking to assess binding affinities relevant to lipid metabolism.
  • Sorafenib treatment caused significant changes in sphingolipid and glycerophospholipid metabolism.
  • Increased expression of immune-related genes such as Stat1 and Irf1 was observed with decreased Eif4e2 levels.
  • The treatment affected macrophage polarization and secretion of inflammatory factors in the tumor microenvironment.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69fa8eac04f884e66b531132https://doi.org/10.3390/biom16050675
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