Embelia ribes (Vidanga, Jadan) revisited: from traditional Ayurvedic and East Asian use to AI-augmented scaffold-hopping for skin fibrosis with embelin parent and EMB-3 derivative case study

Key Points

• To explore the applications of Embelia ribes in treating skin fibrosis through traditional and modern techniques.
• Reviewed traditional uses of Embelia ribes in Ayurvedic and East Asian practices.
• Applied AI methods for scaffold-hopping in drug development.
• Conducted a case study on embelin and its EMB-3 derivative.
• Found potential applications of embelin in treating skin fibrosis.
• Demonstrated the efficacy of AI-enhanced approaches in drug development.
• Highlighted the integration of traditional knowledge with modern science.