AIM: A) modification in pathogenesis, progression, and tissue repair of endodontic diseases, focusing on its regulatory functions in dental stem cells. METHODS: Two reviewers independently searched four databases for studies published by May 2025. The protocol was registered with PROSPERO (CRD420251233698). The certainty of findings was assessed using the CERQual approach. RESULTS: A regulates tooth morphogenesis through WTAP-SHH and METTL3-NFIC pathways. CONCLUSIONS: A modification as an important epitranscriptomic regulator that modulates inflammation and repair in endodontic diseases. Further clinical studies are needed to validate these mechanisms and their therapeutic potential.
Liao et al. (Mon,) studied this question.