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May 6, 2026Journal of Virology0 citationsOpen Access

Transcriptional transactivation turns human iPSC-derived macrophages into an adenovirus-producing cell state

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MSMaarit SuomalainenWHWalther HaenselerJKJonas Kolibius

Key Points

  • To investigate the effects of transcriptional transactivation on iPSC-derived macrophages and their role in viral reactivation.
  • Utilized human iPSC-derived macrophages
  • Induced transcriptional transactivation
  • Monitored dormant virus reactivation
  • Analyzed epigenetic signals
  • Transcriptional transactivation successfully converted macrophages into adenovirus-producing cells
  • Dormant viruses were reactivated
  • Macrophages were shown to serve as reservoirs for HIV and herpesvirus

Abstract

and reactivate dormant virus via epigenetic signals. IMPORTANCE: , in line with the notion that these cells resist immune clearance and serve as reservoirs for HIV, herpesvirus, SARS-CoV-2, or rubella virus infections.

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Cite This Study

Suomalainen et al. (2026) studied this question.

synapsesocial.com/papers/69fa983604f884e66b531f12https://doi.org/10.1128/jvi.00392-26
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