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May 6, 2026The Analyst1 citations

Differentiation of Disaccharide Isomers via Diagnostic-Ion-Weighted Spectral Library Searching using Data from Tandem MS Analysis of Chloride Adducts

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SXShixiang XuABAbraham K. Badu-TawiahSASantosh R. Acharya

Key Points

  • This research aims to differentiate disaccharide isomers using tandem mass spectrometry data.
  • Utilized diagnostic-ion-weighted spectral library searching.
  • Analyzed tandem MS data from chloride adducts of disaccharide isomers.
  • Focused on identifying rare sugars and their isomers.
  • Demonstrated effective differentiation of over 50 saccharide isomers.
  • Found potential applications in food science and pharmaceuticals.
  • Highlighted the significance of structural complexity in isomerization.

Abstract

Rare sugars, comprising of over 50 known saccharide isomers, have broad significance in food science, pharmaceuticals, and biomedical applications. However, the inherent structural complexity (due to isomerization) and low natural...

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Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/69fa986a04f884e66b532234https://doi.org/10.1039/d6an00268d
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