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May 6, 2026Diagnosis

Multicenter reference limits of hs-cTnI and NT-proBNP in a Chinese cohort

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Authors

YXYuxin XuQLQianjin LiHXHuabin Xie

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Overview

Multicenter study established reference intervals for nt-probnp and hs-ctni in plasma, indicating improved cardiovascular risk stratification.

Key Points

  • The central aim was to establish age- and sex-specific reference intervals for hs-cTnI and NT-proBNP in a Chinese cohort.
  • Validated analytical performance of hs-cTnI and NT-proBNP assays.
  • Established reference intervals using nonparametric methods from IFCC-compliant cohorts.
  • Measured hs-cTnI and NT-proBNP on a fully automated chemiluminescence platform.
  • Achieved high sensitivity and specificity for hs-cTnI and NT-proBNP.
  • Established reference intervals for hs-cTnI at 11.97 ng/L for males and 11.61 ng/L for females.
  • Determined 97.5th percentile URLs of NT-proBNP at 145.00 ng/L overall.

Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/69fa989404f884e66b5324b6https://doi.org/10.1515/dx-2026-0045
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