Background: The primary objective of periodontal therapy is to restore the compromised periodontium through regenerative processes. Platelet-rich fibrin (PRF) is a vital biomaterial in this context due to its rich concentration of growth factors within a fibrin matrix. Aim: This study aimed to compare the efficacy of leukocyte-PRF block (L-PRF block) and advanced PRF (A-PRF) combined with bone graft (hydroxyapatite) in treating infrabony defects (IBDs). Materials and Methods: Forty sites with IBDs were randomly assigned to two groups: Group A received A-PRF with bone graft, and Group B received L-PRF block. Criteria for inclusion included probing pocket depth (PPD) ≥5 mm, clinical attachment loss (CAL) ≥3 mm, gingival index (GI) ≥1, and evidence of IBDs ≥ 3 mm observed via cone beam computed tomography. Measurements of GI, PPD, CAL, crestal level (CL), and bone fill were recorded at baseline, 3 months, and 6 months. Results: Both groups showed significant reductions in GI at the 6-month mark ( P < 0.05). In Group A, PPD decreased from 6.850 ± 1.2258 (baseline) to 3.750 ± 0.9105 (6 months), and CAL decreased from 11.100 ± 1.8035 to 8.000 ± 2.2243. In Group B, PPD reduced from 7.500 ± 0.8885 to 3.250 ± 0.5501, and CAL reduced from 11.250 ± 1.5517 to 7.000 ± 1.7472 at 6 months. Intergroup comparisons showed a better outcome for PPD in Group A, while CAL differences were statistically non-significant. IBD measurements and bone fill comparisons between the groups were also non-significant. Conclusion: In conclusion, both L-PRF block and A-PRF combined with bone graft showed significant improvements in assessed parameters over six months. However, there were no significant differences between the two groups, indicating both treatments are effective for addressing IBDs.
Kumar et al. (2026) studied this question.