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May 6, 2026DiagnosticsOpen Access

Endocrine Autoimmunity and Inflammatory Signatures in Pediatric Celiac Disease: Context-Dependent Patterns

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Authors

MGMarta GrecoMMMaria MirabelliRMRoberta Misiti

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Overview

Retrospective analysis shows no increase in autoantibodies in pediatric Celiac disease, suggesting tailored diagnostic approaches.

Key Points

  • This study aims to evaluate endocrine autoantibodies and inflammatory profiles in children with Celiac disease.
  • Retrospective cross-sectional study of 240 children suspected of Celiac disease and/or autoimmune endocrine disorders.
  • Laboratory evaluation included blood counts, thyroid function tests, and autoantibody tests.
  • A subgroup analyzed cytokine levels using multiplex cytokine analysis.
  • Celiac disease was not linked to increased thyroid or pancreatic autoimmunity.
  • Distinct sex-related differences observed in cytokine levels, particularly higher IL-2 in girls with Celiac disease.

Cite This Study

Greco et al. (2026) studied this question.

synapsesocial.com/papers/69fa989404f884e66b532570https://doi.org/10.3390/diagnostics16091330
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Also Consider

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  1. 1Celiac Disease in Children With Type 1 Diabetes: The Usefulness of Screening— 25 years of Experience in a Single Center2025 · 2 citations
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  3. 3Association between Autoimmune Hepatitis and Celiac Disease among Egyptian Children and Adolescents2024
  4. 4Celiac Disease Among Patients with Type 1 Diabetes Mellitus2025
  5. 5Assessment of Gene Expression Levels of Immune Markers in Celiac Desease Patients2025