Observational study finds lower thyroid hormone levels and higher mortality rates in CKRT patients, highlighting severe complications.
Key Points
Investigate the effects of continuous kidney replacement therapy on thyroid function and hormone clearance during acute kidney injury and end-stage kidney disease.
Prospective, single-center observational study
Enrolled 50 ICU patients on CKRT and 50 control ICU patients
Measured serum TSH, fT4, fT3, and rT3 at multiple time points
Employed statistical analyses including linear mixed modelling and ANOVA with FDR correction.
CKRT patients had lower fT4 and fT3 levels compared to controls
TSH and fT4 were detected in CKRT effluent, indicating clearance
Severe and persistent non-thyroidal illness syndrome observed in CKRT cohort