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May 6, 2026Marine Drugs1 citationsOpen Access

Evaluating Schoenoplectus californicus for Antioxidant and Psychopharmacological Properties

Schoenoplectus californicus (C.A. Mey.) Soják: Chemical Profile, Antioxidant Capacity, Psychopharmacological Exploration and Analgesic Activity

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Authors

JCJulio Campos-FloriánGGGladys Galliani-HuamanchumoACAlessandra Victoria Campos-Bazán

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Overview

This investigation reveals antioxidant capacity and psychopharmacological effects in Schoenoplectus californicus, indicating its potential as an analgesic source.

Key Points

  • The aim was to evaluate the chemical profile, antioxidant capacity, and pharmacological effects of Schoenoplectus californicus.
  • Conducted phytochemical screening and LC–MS/MS analyses for chemical characterization.
  • Assessed antioxidant activity using DPPH and ABTS assays.
  • Evaluated psychopharmacological effects using various behavioral tests in Balb/c mice, with diazepam and tramadol as controls.
  • Utilized in silico PASS and BOILED-Egg analyses to predict pharmacological mechanisms.
  • Extract displayed significant antioxidant activity with IC50 values of 0.7319 mg/mL for DPPH and 0.6207 mg/mL for ABTS.
  • Anxiolytic effects were noted at 50 mg/kg, while sedative effects were observed at 200 mg/kg.
  • Significant analgesic activity was demonstrated at 50 mg/kg in behavioral tests.
  • Predictive analyses suggested some compounds could cross the blood–brain barrier, with GABA aminotransferase inhibition suggested as a mechanism.

Cite This Study

Campos-Florián et al. (2026) studied this question.

synapsesocial.com/papers/69faa25e04f884e66b53306bhttps://doi.org/10.3390/md24050160
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