Lactation for ≥6 months was associated with a favorable metabolomic profile, with specific lactation-increased metabolites inversely associated with incident diabetes (HRs 0.88 and 0.90, p<0.05).
Cohort (n=194)
Does lactation duration ≥6 months improve maternal serum metabolomic profiles and reduce incident diabetes and CVD in parous Hispanic/Latino women?
Longer lactation duration (≥6 months) is associated with a favorable maternal serum metabolomic profile, which may partly explain its protective effects against incident diabetes and CVD in Hispanic/Latino women.
Estimación del efecto: HR 0.88 and 0.90
valor p: p=<0.05
Introduction: Lactation has been associated with improved long-term cardiometabolic health in women, but the underlying mechanisms remain unclear. Methods: We studied 194 parous women (mean age: 32.8 years) from the HCHS/SOL with singleton births and self-reported lactation information. A total of 694 serum metabolites were profiled a median of 3 years (IQR: 1-4) after delivery. Lactation duration was categorized as 1.2 and FDR-adjusted p<0.05). We examined the correlations between selected metabolites and cardiometabolic traits. We further examined the prospective associations of selected metabolites with incident diabetes (without baseline diabetes, n=2,341) and CVD (without baseline CVD, n=2,968) over 12 years of follow-up among parous women in the HCHS/SOL. Results: In this study, 26 (13.4%) women reported no lactation for this birth, 100 (51.5%) lactated <6 months, and 68 (35.1%) lactated ≥6 months. Compared with <6 months (n=126), lactation for ≥6 months (n=68) was associated with 46 metabolites, including lower levels of 37 metabolites (e.g., amino acid derivatives involved in energy balance and methylation process and glycerophospholipids key membrane and lipoprotein components linked to dyslipidemia), and higher levels of 9 metabolites (e.g. certain plasmalogens antioxidant phospholipids and sulfated steroids involved in hormonal and metabolic regulation). Most lactation-increased metabolites were positively correlated with triglycerides and LDL cholesterol, while many lactation-decreased metabolites were positively correlated with HDL cholesterol. Furthermore, 17 metabolites (e.g., N-acetylvaline and 3,4-dihydroxybutyrate) that were higher in women with <6 months lactation, were associated with increased risk of incident diabetes or CVD (HRs per SD range:1.12-1.64, p<0.05); while 2 metabolites (pregnenolone sulfate and a plasmalogen), higher in women with ≥6 months lactation, were inversely associated with incident diabetes (HRs per SD: 0.88 and 0.90, p<0.05) ( Figure 1 ). Conclusion: Longer lactation duration was associated with a favorable maternal serum metabolomic profile 1-4 years after delivery, which may partly explain the protective effects of sustained lactation on diabetes and CVD risk among Hispanic/Latino women.
Wang et al. (Tue,) conducted a cohort in Cardiometabolic Disease (n=194). Lactation ≥6 months vs. Lactation <6 months was evaluated on Incident diabetes (HR 0.88 and 0.90, p=<0.05). Lactation for ≥6 months was associated with a favorable metabolomic profile, with specific lactation-increased metabolites inversely associated with incident diabetes (HRs 0.88 and 0.90, p<0.05).