Retrospective analysis highlights digital rectal examination's limited role in predicting cancer in biopsy cohorts, implying specific testing pathways influence results.
Key Points
To quantify the role of digital rectal examination in predicting clinically significant prostate cancer based on biopsies.
Retrospective analysis of 666 consecutive prostate biopsies at a single academic center.
Used multivariable logistic regression models to analyze factors influencing cancer prediction.
Assessed Discrimination using AUC and likelihood ratio tests.
csPCa prevalence was found to be 30.7% in patients undergoing biopsy.
DRE showed significant association with csPCa, although with modest discrimination gain.
Findings indicated that the role of DRE is context-dependent based on the presence of mpMRI.