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May 7, 2026AntibioticsOpen Access

The Efficacy of Sodium Hypochlorite in Combination with Hyaluronic Acid as an Adjunct to Non-Surgical Periodontal Treatment: A Systematic Review

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Authors

QFQonita FeriaISInggrid Ratna Sari SoegihartoNPNanda Denia Astika Putri

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Overview

Systematic review evaluates sodium hypochlorite and hyaluronic acid's role in improving periodontal outcomes, suggesting benefits in deep pockets.

Key Points

  • To evaluate the effectiveness of sodium hypochlorite combined with hyaluronic acid in non-surgical periodontal treatment.
  • Systematic review of scientific literature
  • Searched five electronic databases
  • Used PRISMA criteria for study selection
  • Examined randomized studies using Cochrane Risk of Bias tool
  • Reviewed case series studies with Joanna Briggs Institute checklist.
  • Included four studies: two randomized controlled trials and two case series
  • PPD reduction ranged from 1.5 to 5.8 mm
  • CAL gain ranged from 1.5 to 5.3 mm
  • BOP reduction ranged from 57.5% to 65.6%
  • Improvements more pronounced in deeper periodontal pockets.

Cite This Study

Feria et al. (2026) studied this question.

synapsesocial.com/papers/69fbe357164b5133a91a285dhttps://doi.org/10.3390/antibiotics15050428
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