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May 7, 2026Journal of Agricultural and Food Chemistry0 citationsOpen Access

A Fungal p -Terphenyl Prenyltransferase for Regioselective C -Prenylation of Flavonoids and Other Compounds Bearing ortho -Dihydroxyphenyl Moieties

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DJDaniel J. JanzenJZJenny ZhouSLSvenja Losert

Key Points

  • Investigate the regioselective prenylation of flavonoids by UcdE, focusing on its specificity.
  • Characterization of UcdE enzyme activity on flavonoids
  • Assessment of prenylation positions
  • Evaluation of specificity compared to known prenyltransferases
  • UcdE specifically prenylylates flavonoids at position C-2'
  • Demonstrates higher selectivity than typical prenyltransferases
  • Expands potential for developing bioactive compounds for pharma and nutrition

Abstract

2'-prenylation of flavonoids, differing clearly from the prenylation positions of most known prenyltransferases at C-6, C-8 or C-3'. The distinguishing properties of UcdE highlight its unprecedented specificity among prenyltransferases as a promising tool for selective biocatalysis, expanding the range of bioactive compounds for pharmaceutical and nutritional applications.

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Cite This Study

Janzen et al. (2026) studied this question.

synapsesocial.com/papers/69fbe357164b5133a91a2a07https://doi.org/10.1021/acs.jafc.6c03303
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