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May 7, 2026Analytical Chemistry

Hypoxia-Activated Probe for Targeted Photoacoustic Imaging and Photothermal Modulation of Adipose Tissue in Obesity

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Authors

LXLong XiaoRLRui LiXZXingyu Zhu

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Overview

Hypoxia-activated probe improves photoacoustic imaging and reduces obesity parameters in mice, indicating a new therapeutic strategy.

Key Points

  • This research aims to develop a hypoxia-activated probe for targeted imaging and treatment of obesity-related adipose tissue.
  • Developed a hypoxia-activated phototheranostic probe (CBH-O) utilizing a caged Aza-BODIPY fluorophore.
  • Administered CBH-O nanoparticles via intraperitoneal injection in obese mice.
  • Conducted photoacoustic imaging and assessed photothermal conversion efficiency.
  • Evaluated changes in adipose tissue browning, lipolysis, and inflammation markers.
  • Reduced body weight by 15.6% and adipose tissue mass by 65%.
  • Decreased cholesterol levels in serum by 49.1% and triglycerides by 30.3%.
  • Lowered insulin levels by 75.7% and pro-inflammatory markers (IL-6, MCP-1).
  • Increased anti-inflammatory marker (IL-10).

Cite This Study

Xiao et al. (2026) studied this question.

synapsesocial.com/papers/69fbe382164b5133a91a2af5https://doi.org/10.1021/acs.analchem.6c01395
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