Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 7, 2026British Journal of CancerOpen Access

Targeting NUDT21-mediated alternative polyadenylation of oncogenes ameliorates colorectal cancer malignancy and metastasis

View Full Paper
Ask AI
Bookmark
Share

Authors

SLShih-Chieh LinYTYa-Chuan TsaiJWJui-Lin Wang

Discussion

Loading...

Member takes

Overview

Systematic analysis identifies NUDT21 as a therapeutic target in colorectal cancer, reducing malignancy and improving prognosis.

Key Points

  • Investigate NUDT21's role in colorectal cancer metastasis and its potential as a therapeutic target.
  • Conducted bioinformatic analysis to identify key genes in colorectal cancer.
  • Performed loss-of-function and gain-of-function experiments in vitro and in vivo.
  • Analyzed survival data related to NUDT21 levels in cancer patients.
  • NUDT21 overexpression is linked to poor prognosis in colorectal cancer patients.
  • NUDT21 knockdown reduces cancer cell growth and malignancy traits.
  • RNA-seq and RIP-seq indicate NUDT21 enhances expression of oncogenes related to CRC progression.

Cite This Study

Lin et al. (2026) studied this question.

synapsesocial.com/papers/69fbe382164b5133a91a2b36https://doi.org/10.1038/s41416-026-03451-9
View Full Paper
Ask AI
Bookmark
Share