PRKN/parkin-mediated control of SNCA (synuclein alpha) and chaperone-mediated autophagy are defective in cellular, mice models and Parkinson disease-affected brains

Key Points

• This research aims to explore the role of PRKN in controlling synuclein alpha and autophagy in Parkinson disease.
• Investigation of PRKN/parkin function in cellular models.
• Analysis of synuclein alpha and autophagy in mice models.
• Examination of brain tissue from Parkinson disease-affected individuals.
• Defective control of synuclein alpha noted in cellular and mice models.
• Autophagy processes mediated by chaperones were impaired in Parkinson disease-affected brains.