Experimental colitis reduced sociability and increased aggressive behaviors in mice, indicating diosgenin may improve outcomes by alleviating neuroinflammation.
Key Points
Assess diosgenin's effects on inflammation and autistic-like behaviors in mice with colitis.
Induced colitis in mice using acetic acid and divided them into five treatment groups.
Administered diosgenin and saline for seven consecutive days at specified doses.
Conducted behavioral tests for sociability, social preference, and memory, followed by dissection of colon and hippocampus.
Colitis caused significant behavioral changes, including reduced sociability and increased aggression.
Diosgenin treatment mitigated the negative behavioral effects and reduced inflammatory markers in both the colon and hippocampus.