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May 7, 2026Journal of Chromatography B0 citationsOpen Access

Evaluation of extraction methods for the determination of urinary sulfatides by LC-MS/MS

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JJJoachim JandaFBFriederike BürgerSGStefanie Geiger

Key Points

  • To evaluate different extraction methods for urinary sulfatides using LC-MS/MS.
  • Conducted batch experiments to extract sulfatides from urine
  • Assessed four different extraction techniques
  • Evaluated extraction efficiencies and matrix effects for 16 isoforms
  • Validated the most suitable extraction method
  • Presented application data from patient samples
  • Identified the most efficient extraction technique
  • Found significant matrix effects impacting sulfatide measurement

Abstract

• Batch experiments to extract sulfatides from urine were performed. • Four different extraction techniques were assessed. • Extraction efficiencies and matrix effects were evaluated for 16 isoforms. • The most suitable method has been validated. • Its application to patient samples is presented.

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Cite This Study

Janda et al. (2026) studied this question.

synapsesocial.com/papers/69fbe3ca164b5133a91a319chttps://doi.org/10.1016/j.jchromb.2026.125106
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