De novo construction of C-O axial chirality via cobalt-catalyzed atroposelective C-H activation/annulation

Key Points

• The aim is to construct C-O axial chirality using cobalt-catalyzed methods.
• Utilized cobalt as a catalyst for C-H activation
• Implemented atroposelective annulation techniques
• Focused on the synthesis of axially chiral compounds
• Successfully synthesized C-O axially chiral compounds
• Highlighted the uniqueness of the produced atropisomers
• Demonstrated the effectiveness of cobalt-catalyzed methods