Ligand Control Overrides Intrinsic Site Selectivity in C–H Borylation of Phenol and Aniline Derivatives

Key Points

• The aim is to investigate how ligand design affects site selectivity in C-H borylation reactions.
• Utilized a designed ligand in conjunction with an iridium catalyst for C-H borylation reactions.
• Focused on phenol and aniline derivatives as substrates for the study.
• Demonstrated that ligand control can effectively alter the intrinsic site selectivity during C-H borylation.
• Achieved enhanced regioselectivity compared to traditional methods without the ligand.