Breast cancer-related lymphedema (BCRL) is a debilitating complication post axillary lymph node dissection (ALND). The clinical paradigm is changing from palliative decongestive therapies to primary surgical prevention. Immediate lymphatic reconstruction (ILR) by supermicrosurgery preempts lymphatic stasis before irreversible fibrosis occurs. We critically assessed current literature, combining information from randomized controlled trials (RCTs) and meta-analyses available up to 2026. Surgical procedures and clinical effectiveness will be examined in this review, with an emphasis on its contributions to adjuvant radiotherapy, Total Breast Anatomy Restoration (TBAR) and robotic-assisted supermicrosurgery. A large meta-analysis of 791 patients shows that ILR reduces the BCRL risk, producing a 69% reduction in incidence of lymphedema. Advanced intraoperative techniques (FITC mapping, vein grafts) and robotic platforms have fine-tuned anastomotic patency to 99.38%. Adjuvant radiotherapy delivers extensive ionizing doses to the micro-anastomosis, but the protective effect lasts. TBAR effectively combines vascularized lymph node transfer (VLNT) with autologous flaps for therapeutic reconstruction. ILR creates a new standard of care for high-risk patients. However, routine use in high-risk care needs to be risk stratified for cost-effectiveness. Improved research must focus on standardized diagnostic criteria and long-term studies of irradiated microvascular anastomoses.
Enríquez et al. (Mon,) studied this question.