To investigate whether the Atherogenic Index of Plasma (AIP) is independently associated with 90-day functional outcomes in patients with moderate-to-severe acute ischemic stroke (AIS) of presumed atherosclerotic etiology involving the middle cerebral artery (MCA) territory after intravenous thrombolysis (IVT), and to analyze its correlation with infarct core volume. This single-center retrospective cohort study consecutively enrolled AIS patients who underwent IVT within 9 h of onset, met CT perfusion (CTP) mismatch criteria (hypoperfusion volume/infarct core volume ratio > 1.2; mismatch volume > 10 mL; and infarct core volume 0.28) had a more than tenfold increased risk compared to those in the lowest tertile ( 0.28) had a more than tenfold increased risk of poor outcome. The predictive value of AIP is particularly evident within the standard time window (≤ 4.5 h). Although AIP is positively correlated with infarct core volume, it provides complementary prognostic information—offering high sensitivity suitable for early risk stratification. These findings, derived from a hypothesis-generating study, suggest that AIP may contribute to risk stratification, particularly in resource-limited settings or as part of a multimodal prediction panel. Prospective multicenter studies are warranted for further validation.
Hou et al. (Tue,) studied this question.