AA V-Mediated overexpression of the CB1 receptor in a mouse model of retinal degeneration: perspectives for a nationally developed gene therapy in a rare disease

Key Points

• The research aims to investigate the effects of AA-mediated overexpression of the CB1 receptor in a mouse model of retinal degeneration.
• Utilized a mouse model of retinal degeneration for intervention.
• Assessed the overexpression of the CB1 receptor in the retina using gene therapy techniques.
• Evaluated the functional outcomes related to retinal health post-treatment.
• Significant improvement in retinal function observed after CB1 receptor overexpression.
• Reduction in degeneration markers, indicating potential therapeutic benefits of the gene therapy approach.
• Findings suggest a promising avenue for treating rare retinal diseases.

Abstract