Functional aplication of the iCasp9 suicide gene system as a safety mechanism for CAR-T Cells

Key Points

• This research aims to evaluate the iCasp9 suicide gene system as a safety mechanism in CAR-T cell therapies.
• Utilized the iCasp9 system in CAR-T cell design.
• Conducted evaluations at the International Symposium on Immunobiologicals.
• Examined effects on safety and efficacy.
• Demonstrated enhanced safety profile of CAR-T cells with iCasp9.
• Notable reduction in adverse effects related to CAR-T therapy.

Abstract