Yi-Shen-Hua-Shi granule added to supportive care reduces proteinuria in IgA nephropathy: a multicenter randomized controlled trial

Key Points

• The research aims to evaluate the impact of Yi-Shen-Hua-Shi granule on proteinuria levels in patients with IgA nephropathy when added to supportive care.
• Multicenter randomized controlled trial design
• Patients received either Yi-Shen-Hua-Shi granule or standard supportive care
• Primary outcome measured was proteinuria levels
• Yi-Shen-Hua-Shi granule led to a significant reduction in proteinuria compared to supportive care alone (p<0.01)
• No significant differences in estimated glomerular filtration rate or adverse events between groups
• Greater reduction in proteinuria observed in patients with high baseline proteinuria

Abstract