What question did this study set out to answer?

This research aims to explore molecular editing to create new chemical structures of bilobalide.

May 8, 2026Open Access

Molecular Editing of Bilobalide: Regioselective C-Ring Lactam Formation

Key Points

This research aims to explore molecular editing to create new chemical structures of bilobalide.
Activated a benzoylated intermediate for cyclization.
Developed fused bilobalide lactam scaffolds.
Successfully delivered regioselective C-ring lactam structures.
Expanded the chemical space of bilobalide for biological applications.

Abstract

activation of a benzoylated intermediate followed by cyclization, delivering fused bilobalide lactam scaffolds. This work expands the accessible chemical space of bilobalide for future biological exploration.

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Cite this study

Wang et al. (Tue,) studied this question.

www.synapsesocial.com/papers/69fd7d94bfa21ec5bbf05fca — DOI: https://doi.org/10.1021/acs.orglett.6c01262

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Authors

Wenjing Wang

Stephan Scheeff

Sam C. K. Hau

Journals

Organic Letters

Actions

Institutions

University of Hong Kong

Chinese University of Hong Kong

Neuroscience Institute

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Molecular Editing of Bilobalide: Regioselective C-Ring Lactam Formation

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Cite this study

Also consider

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion