Polysaccharide-Based Soluble Microneedle Transdermal Delivery of Curcumin Synergized with Photothermal Therapy for Acne Treatment

Key Points

• This research aims to assess the efficacy of a polysaccharide-based microneedle system delivering curcumin combined with photothermal therapy for treating acne.
• Developed a soluble microneedle system using polysaccharides for transdermal delivery of curcumin.
• Evaluated the treatment's effects on skin thickness and acne symptoms in a controlled clinical setting.
• Utilized photothermal therapy alongside microneedle application.
• Demonstrated significant improvement in acne symptoms compared to baseline.
• Restored skin thickness to near-normal levels after treatment.

Abstract