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May 8, 2026Open Access

Inhibitory effects of thiophene-2-thiazole hybrids against sensitive strains and resistant clinical isolates of Mycobacterium tuberculosis

Key Points

The research aims to evaluate the bactericidal effects of thiophene-2-thiazole hybrids against various strains of Mycobacterium tuberculosis.
Assessed bactericidal activity of compound 3c under nutrient-starvation conditions.
Compared performance against isoniazid in a dormancy model.
Conducted cytotoxicity assays in HepG2 and Vero E6 cells.
Compound 3c showed significant bactericidal activity, outperforming isoniazid in dormancy conditions.
Low cytotoxicity was observed with an IC₅₀ value greater than 100 μM.

Abstract

. Compound 3c retained bactericidal activity under nutrient-starvation conditions and outperformed isoniazid (INH) in a dormancy model. Cytotoxicity assays in HepG2 and Vero E6 cells showed low toxicity (IC₅₀ > 100 μM). These findings identify 3c as a promising lead scaffold for anti-TB drug development.

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Authors

Paulo Fernando da Silva Santos-Júnior

Valnês S. Rodrigues-Junior

Monalisa Silva

Journals

Bioorganic & Medicinal Chemistry Letters

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Institutions

Universidade Federal do Rio Grande do Norte

Pontifícia Universidade Católica do Rio Grande do Sul

Universidade Federal da Paraíba

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Building similarity graph...

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Inhibitory effects of thiophene-2-thiazole hybrids against sensitive strains and resistant clinical isolates of Mycobacterium tuberculosis

Key Points

Abstract

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Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

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