Glucose Oxidase‐Powered Ferrium MOFs for Self‐Amplifying Fenton Catalysis and Photothermal Therapy

, further boosting Fenton-like reactions. Our results demonstrate that FHMGA exhibits significant anti-tumor efficacy with minimal systemic toxicity. The triple synergy of oxidative damage from chemodynamic therapy, thermal ablation from photothermal therapy, and metabolic disruption via glucose oxidase significantly inhibits cancer cell growth by overcoming antioxidant-mediated limitations. Self-amplifying Fenton catalysis, while responsive degradation reduces systemic toxicity. This work advances precise cancer therapy by establishing a chemotherapy-free, multi-responsive synergistic system, addressing critical bottlenecks of ferrium-based MOFs and providing a safer, more effective strategy for tumor-specific treatment.