Polymorphism of Interleukin-1β 511 Gene in Women with Breast Tumor in Babylon Province

Abstract Background: Interleukin-1 (IL-1) is a member of the cytokine family that is, crucial for initiating and regulating inflammatory and immune responses. Objective: It has been demonstrated that the pro-inflammatory cytokine interleukin-1β (IL1β 511) affects breast tumor susceptibility. Our study sought to determine whether the IL1β 511 gene polymorphism and susceptibility to breast tumors are related. This association between the risk of breast tumors and the IL1β 511 polymorphism has been established. Materials and Methods: The blood samples were collected from 50 healthy women and 100 nonhealthy ones. Following collection, DNA extraction was performed on the samples. Restrictions fragment polymorphism and polymerase chain reaction were used to analyze the IL-1β 511 promoter primer. Results: According to our findings, all genetic models significantly associated common SNPs in IL-1β 511 (rs16944) with breast tumor risk. IL-1β 511 polymorphism significantly decreased breast tumor risk between patients and healthy—control (CT, CC, TT: OR 2.29, 0.43, 0.54 CI 95, P value: 0.02*, 0.01*, 0.54, respectively). Conclusion: The IL-1β 511 (rs16944) polymorphisms were significantly associated with the risk of breast tumor.