Practical and Scalable Entry to Halogenated 1,4-Thiazines Through a Domino Morin-Rearrangement/Halogenation of N,S-Acetals and their Arylation Based on Suzuki-Miyaura Coupling

Key Points

• To develop a practical and scalable method for synthesizing halogenated thiazines.
• Utilized Morin-rearrangement of N,S-acetals.
• Conducted halogenation to introduce halides at the α-position of thiazines.
• Employed Suzuki-Miyaura coupling for arylation.
• Successfully synthesized thiazines with halides at α-position.
• Demonstrated one or two-step synthesis efficiency without extensive conditions.
• Provided a new scalable route that could enhance future applications in organic synthesis.

Abstract