What question did this study set out to answer?

This research aims to develop a responsive drug delivery system that co-delivers curcumin and cinnamaldehyde to disrupt tumor redox homeostasis.

May 8, 2026

ROS-Responsive Polyprodrug Co-Delivery of Curcumin and Cinnamaldehyde to Disrupt Tumor Redox Homeostasis for Anticancer Therapy

Key Points

This research aims to develop a responsive drug delivery system that co-delivers curcumin and cinnamaldehyde to disrupt tumor redox homeostasis.
Utilized ROS-responsive polyprodrug nanoparticles for drug delivery.
Conducted in vivo experiments to assess drug accumulation and tumor inhibition.
Measured tumor growth suppression compared to control groups.
Observed a tumor inhibition rate of up to 86% with PCC nanoparticles.
Free curcumin and cinnamaldehyde showed lower efficacy with concentrations of 21.66 μM and 193.06 μM respectively.
Demonstrated significantly suppressed tumor growth in experimental groups using the ROS-responsive delivery system.

Abstract

) of 13.93 μM, which is markedly lower than the 21.66 μM for free Cur and 193.06 μM for free CA. In vivo experiments confirmed that PCC nanoparticles could accumulate at tumor sites via the enhanced permeability and retention (EPR) effect, achieving a tumor inhibition rate of up to 86% and significantly suppressing tumor growth compared to other experimental groups. This work constructs an intelligent delivery platform based on a ROS-responsive drug delivery system, offering a promising strategy for the efficient delivery of natural antitumor drugs.

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Discussion

Authors

Congshu Feng

J I A H U I Wu

Zilong Chen

Journals

ACS Applied Materials & Interfaces

Actions

Institutions

Wuhan University of Technology

State Key Laboratory of Advanced Technology For Materials Synthesis and Processing

ROS-Responsive Polyprodrug Co-Delivery of Curcumin and Cinnamaldehyde to Disrupt Tumor Redox Homeostasis for Anticancer Therapy

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study