Carboxyterminal-Telopeptide Pyridinoline Cross-Links of Type I Collagen (ICTP) as a Diagnostic Biomarker for Periodontitis and Osteoporosis in Postmenopausal Women

Abstract Background: The diagnosis of osteoporosis and periodontitis at a molecular level is still compromised and the clinical techniques may be prone to errors due to different factors. Available biomarkers in the oral biofluid such as carboxyterminal-telopeptide pyridinoline cross-links of type I collagen (ICTP) could provide solutions for these issues. Objective: Is to assess the diagnostic ability of salivary ICTP in predicting osteoporosis and periodontitis. Materials and Methods: This study was conducted on 160 postmenopausal women with ages ranging from 50 to 70 years old, divided into four groups: the first group: women with osteoporosis and periodontitis, the second group: women with osteoporosis and periodontally healthy, the third group: women non-osteoporosis with periodontitis, and the fourth group: women systematically and periodontally healthy. Unstimulated saliva was taken, and a periodontal examination was performed. The salivary level of ICTP was estimated by an enzyme-linked immunosorbent assay (ELISA). Results: The results showed that ICTP had an excellent predictor for osteoporosis in the presence and absence of periodontitis with area under the curve (AUC; 0.962, 1.000) at the proposed cutoff point at (9.920, 7.1145), respectively. As well it was a very good and excellent predictor for periodontitis in the presence and absence of osteoporosis with AUC (0.892, 0.999) at the proposed cutoff point of 10.264 and 6.657, respectively. Conclusion: ICTP could be considered a predictor for the diagnosis of osteoporosis in the presence and absence of periodontitis, and in diagnosing periodontitis in the presence and absence of osteoporosis.