How I Treat: Immune dysregulation in Down syndrome

Key Points

• This research aims to address the underrecognized immune dysregulation in Down syndrome and its treatment challenges.
• Utilized clinical vignettes to illustrate treatment strategies for immune dysregulation in Down syndrome.
• Described various immune-related conditions associated with Down syndrome.
• Discussed the complications in treating immune dysregulation using immunomodulators.
• Emphasized the heightened infection risk in Down syndrome due to underlying immunodeficiency.
• Outlined the diverse range of autoimmune and autoinflammatory diseases observed in individuals with Down syndrome.
• Highlighted the challenges faced in effectively treating these immune complications.

Abstract