Cellular senescence: Molecular signatures and cellular remodeling

Cellular senescence, a state of stable cell-cycle arrest accompanied by profound metabolic and secretory changes, has emerged as a central hallmark of aging and a key contributor to age-associated diseases. Despite the great progress in understanding the characteristics, the underlying molecular mechanisms, and the role of senescent cells in several pathologies, many crucial issues remain unresolved. In this 'In the Limelight' special issue of FEBS Open Bio, three review articles deal with the accurate detection of senescent cells in vivo, changes in intercompartmental communication in senescent cells, and the role of lipid metabolism in neuronal senescence.