Associations of Mitochondrial Heteroplasmy in Blood Monocytes with Its Phenotypic Indices and Cardiometabolic Parameters in Metabolic Syndrome: A Pilot Cross-sectional Study

Key Points

• This study aims to explore how variations in mitochondrial DNA in blood monocytes relate to metabolic syndrome characteristics.
• Cross-sectional study design
• Focused on patients with metabolic syndrome
• Analyzed associations between mtDNA variability and cytokine levels, gene expression, and cardiometabolic metrics.
• Identified significant correlations between mitochondrial heteroplasmy and cytokine secretion patterns.
• Findings indicate links between mtDNA variability and specific cardiometabolic parameters such as lipid levels.
• Results suggest that mtDNA variability may influence immune responses in metabolic syndrome.

Abstract