When less is more: case study of therapeutic vagus nerve stimulation at low pulse width in a single person

Key Points

• This study aims to explore the effects of reduced pulse width settings in vagus nerve stimulation for improved seizure control in a patient with epilepsy.
• Case study of a 66-year-old woman with genetic generalized epilepsy
• Adjusted vagus nerve stimulation settings including lower signal frequency and reduced pulse width to 130 µsec
• Enabled gradual increases in output current to enhance tolerability.
• Improved tolerability of treatment following adjustments
• Better seizure control observed as a result of lower pulse width and adjusted stimulation settings.

Abstract