The authors of the original article “Characterisation of RNA guanine-7 methyltransferase (RNMT) using a small molecule approach” (DOI: 10.1042/BCJ20240608) would like to correct the Figure Legend of Figure 5. The authors state that the data have been incorrectly presented as as mM rather than μM, resulting in a 1000-fold under-representation of efficacy. They have confirmed that the logged data are correct and aligns with the graphs.The requested correction has been assessed and approved by the Editorial Board. The authors declare that these corrections do not change the results or conclusions of their paper.The corrected Figure Legend reads as follows:Chemical structures of (A) DDD1060606 and (B) DDD1870799. DDD1060606 and DDD1870799 showed >80% inhibition of HsRNMT-RAM activity with determined pIC50s (negative logarithm of half-maximal inhibitory concentration molar) of 5.5 ± 0.2 (IC50 3 μM; Figure 6D and 5.0 ± 0.2 (IC50 10 μM; Figure 6G), respectively.
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David W. Gray
Lesley-Anne Pearson
Alain‐Pierre Petit
Biochemical Journal
University of Dundee
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Gray et al. (Fri,) studied this question.
www.synapsesocial.com/papers/69fd7f65bfa21ec5bbf07e79 — DOI: https://doi.org/10.1042/bcj20240608_cor