Identifying Quiescent Satellite Cells: A Scoping Review of Transcriptomic Markers and Limitations

Key Points

• The aim is to review transcriptomic markers for quiescent satellite cells and identify limitations in current research.
• Scoping review of literature focusing on transcriptomic markers for satellite cell identification.
• Analysis of studies involving murine models and discussions on challenges faced in larger mammals.
• Evaluation of conceptual, technical, and terminological inconsistencies in the field.
• Limited literature on quiescence markers in larger mammals, including humans, pigs, and cattle.
• Identified conceptual and technical challenges in satellite cell analysis affecting transcriptional consistency.
• Emphasized the need for standardized terminology and analyses for clearer cross-species validation.

Abstract