Abstract Number: Esoc2026a703 Characterization of Cardiovascular Risk Factors in the Subacute Phase After Stroke and the Association With Long-Term Mortality

Abstract Background and aims We aimed to investigate the association between major cardiovascular risk factors, including obstructive sleep apnea (OSA) severity, and long-term mortality among patients hospitalized with acute stroke. Methods We conducted a pooled analysis of three previously published studies including patients with ischemic or hemorrhagic stroke admitted to the acute stroke unit at Rigshospitalet Glostrup between 2010 and 2016. All patients underwent overnight polysomnography within the first week of hospital admission. Patients were followed until 1 October 2023. Associations between long-term mortality and cardiovascular risk factors, including OSA, were evaluated using multivariable Cox proportional hazards regression models. Results A total of 137 patients were included. Mean follow-up time from stroke onset to death or end of study period was 9.2 years. Higher OSA severity was associated with increased risk of long-term mortality with a hazard ratio (HR) of 1.14 per 10-unit increase in Apnea-Hypopnea Index (AHI) (95% confidence interval CI 1.00–1.29). Increasing age was also associated with higher mortality risk (HR 1.05 per year; 95% CI 1.02–1.09). Patients without Diabetes Type 1 or 2 had a significantly lower risk of long-term mortality (HR 0.18; 95% CI 0.04–0.89 for type 1 Diabetes and HR 0.41; 95% CI 0.20–0.82 for type 2 Diabetes). No significant associations were observed for Atrial fibrillation, Hypertension, Hypercholesterolemia, Body Mass Index, or Barthel Index for Activities of Daily Living. Conclusions Among patients admitted with acute stroke, higher AHI, older age, and a diagnosis of Diabetes at admission were independently associated with increased long-term mortality. Conflict of interest Kathrine B Sondergaard: nothing to disclose. Sofie Amalie Simonsen: nothing to disclose. Laura Bødker Posaing: nothing to disclose. Helle K Iversen: nothing to disclose. Poul Jørgen Jennum: nothing to disclose. Anders Sode West: nothing to disclose.