Is pulse pressure a mediator in the relationship between hyperoxemia and acute brain injury in veno-arterial extracorporeal membrane oxygenation (VA-ECMO) patients? An ELSO registry study

Key Points

• Investigate the role of pulse pressure in the link between hyperoxemia and acute brain injury in VA-ECMO patients.
• Used ELSO registry data to analyze the relationship between hyperoxemia and acute brain injury.
• Conducted mediation analysis to assess the effect of pulse pressure on the relationship.
• Focused on the non-left vented cohort to evaluate mediation effects.
• Severe hyperoxemia was associated with increased acute brain injury risk, accounting for 8.2% of the total effect when mediated by pulse pressure.
• In the non-left vented cohort, pulse pressure accounted for 14% of the effect size.
• Low pulse pressure itself was not associated with increased acute brain injury risk.

Abstract