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Research Paper | Synapse

May 8, 2026

Synthesis of Clausenamide Isomers and Evaluation of Their Potential as Cortical Neuroplastogens

Key Points

This research aims to synthesize clausenamide isomers and assess their potential to promote cortical synaptogenesis.
Synthesis of various clausenamide isomers
Evaluation of synaptogenic effects in cortical cultures
Assessment of 5-HT2A receptor activity
-Clausenamide isomer demonstrated the highest level of cortical synaptogenesis
Effect size correlated with its function as a 5-HT2A receptor partial agonist

Abstract

-clausenamide exhibited the highest level of cortical synaptogenesis, with this effect likely being dependent on its ability to act as a 5-HT2AR partial agonist.

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Authors

Y

Yongyu Ou

University of California, Davis

Y

Yara A. Khatib

Multidisciplinary Association for Psychedelic Studies

A

Adam Mosswood

Multidisciplinary Association for Psychedelic Studies

Journals

ACS Chemical Neuroscience

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Institutions

University of California, Davis

Institut de Biologie Moléculaire et Cellulaire

Institute of Molecular Medicine

References and Citations

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Cite this study

Ou et al. (Wed,) studied this question.

synapsesocial.com/papers/69fd7fcdbfa21ec5bbf08722 — DOI: https://doi.org/10.1021/acschemneuro.5c00767