Acute myeloid leukemia (AML) is the most frequent type of leukaemia in adults, often with poor outcomes due to the complex genetic landscape and low treatment efficacy. Autophagy, a conserved degradation process, plays an indispensable and context-dependent role in AML. This work explored the prognostic impact of autophagy-related genes compared to known AML-related genes. A two-gene signature (ATG16L1-OPTN) demonstrated that the expression of these autophagy-related genes correlates significantly with overall survival (OS). Cox regression analysis and validation in two larger cohorts (BEATAML2andTCGA LAML) confirmed the association of this signature with worst OS, reinforcing its clinical relevance. These results suggest the ATG16L1-OPTN signature as a novel and robust prognostic marker for predicting OS in AML patients.
Teixeira et al. (Tue,) studied this question.