PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
May 9, 2026Cellular and Molecular Neurobiology0 citationsOpen Access

Spinal Cord Stimulation Alleviates Neuropathic Pain Involves Regulation of the Ca2+/CaN/NFAT4 Pathway in Spinal Dorsal Horn Astrocytes

XLXiaohui LiZWZhen WuRWRongrong Wang

Key Points

  • To investigate how spinal cord stimulation affects the Ca2+/CaN/NFAT4 pathway in astrocytes to alleviate neuropathic pain.
  • Analyzed the influence of spinal cord stimulation on the Ca2+/CaN/NFAT4 pathway in spinal dorsal horn astrocytes.
  • Evaluated astrocyte polarization and cytokine release post peripheral nerve injury.
  • Spinal cord stimulation effectively inhibited NFAT4 nuclear translocation in astrocytes.
  • This intervention significantly suppressed A1-like astrocyte polarization and proinflammatory cytokine release, leading to pain alleviation.

Abstract

/CaN/NFAT4 signaling pathway in spinal dorsal horn caused by peripheral nerve injury, thereby inhibiting NFAT4 nuclear translocation. This suppresses A1-like astrocyte polarization and proinflammatory cytokine release, alleviating neuropathic pain.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69fececcb9154b0b82876042https://doi.org/10.1007/s10571-026-01739-1
Ask AI
Helpful
Bookmark
Share
View Full Paper