Pulse Explore Journal Club Debates Trending Researchers Journals

Home Explore Journal Club Trending

⌘+K

A Novel PET/CT Tracer for Human Urokinase-Type Plasminogen Activator Receptor | Synapse

May 9, 2026Journal of Medicinal Chemistry0 citations

A Novel PET/CT Tracer for Human Urokinase-Type Plasminogen Activator Receptor

View Full Paper

GZGangzhong Zhou XSXudong Sun GCGong Chen

Key Points

This research aims to assess the utility of Ga-PDT02 as a PET radiotracer for visualizing uPAR in aggressive tumors.
Evaluated the pharmacokinetics and imaging performance of Ga-PDT02.
Demonstrated non-invasive visualization of uPAR expression.
Ga-PDT02 showed favorable pharmacokinetics in preclinical models.
Imaging performance supports its potential for detecting aggressive tumors.

Abstract

Ga-PDT02 as a promising uPAR-targeted PET radiotracer with favorable pharmacokinetics and imaging performance, supporting its potential utility for non-invasive visualization of uPAR expression in aggressive tumors.

Ask AI

Helpful

Bookmark

Share

View Full Paper

Ask AI

Helpful

Bookmark

Share

View Full Paper

Cite This Study

Zhou et al. (Wed,) studied this question.

synapsesocial.com/papers/69fececcb9154b0b828761b1 https://doi.org/https://doi.org/10.1021/acs.jmedchem.6c00872

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

110P3Me: A GPC3-Targeted Peptide PET Probe for Subcutaneous and Orthotopic HCC Imaging2025 · 9 citations
2Chemotherapy and Targeted Therapy for Patients With Human Epidermal Growth Factor Receptor 2–Negative Metastatic Breast Cancer That is Either Endocrine-Pretreated or Hormone Receptor–Negative: ASCO Guideline Update2021 · 67 citations
3MSP-induced RON activation upregulates uPAR expression and cell invasiveness via MAPK, AP-1 and NF- B signals in gastric cancer cells2010 · 37 citations
4Metastases in Prostate Cancer2018 · 88 citations
5An Ellagic Acid Coordinated Copper‐Based Nanoplatform for Efficiently Overcoming Cancer Chemoresistance by Cuproptosis and Synergistic Inhibition of Cancer Cell Stemness2023 · 41 citations