cell subpopulation promotes type H-like blood vessel invasion via ANG2/VEGF-A signaling. Notably, reducing type H-like blood vessels or inhibiting ANG2/VEGF-A in aging mice, we observed delayed soft tissue aging and improved locomotor function. These findings reveal an underlying mechanism linking vascular infiltration and pathological cell fate transitions in soft tissue aging, highlighting the therapeutic potential of targeting the coupling of type H-like blood vessels and cell fate transition to delay soft tissue aging.
Miao et al. (Wed,) studied this question.